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One useful research resource would be a healthy

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Unformatted text preview: standing of this aspect of human biology and allow the identification of gene variants that are important for the maintenance of health, particularly in the presence of known environmental risk factors. One useful research resource would be a ‘healthy cohort’, a large epidemiologically robust group of individuals (Box 1) with unusually good health, who could be compared with cohorts of individuals with diseases and who could also be intensively studied to reveal alleles protective for conditions such as diabetes, cancer, heart disease and Alzheimer’s disease. Another promising approach would be rigorous examination of genetic variants in individuals at high risk for specific diseases who do not develop them, such as sedentary, obese smokers without heart disease or individuals with HNPCC mutations who do not develop colon cancer. Grand Challenge II-3 D e v e l o p g e n o m e b a s e d a p p ro a c h e s t o p r e d i c t i o n o f d i s e a s e s u s c e p t i b i l i t y a n d d r u g r e s p o n s e , e a rl y d e t e c t i o n o f ill n e s s , a n d m o l e c u l a r t a x o n o m y o f d is e a s e st a t e s The discovery of vari...
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