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Unformatted text preview: standing of this aspect of human biology and allow the identification of gene
variants that are important for the maintenance of health, particularly in the presence of
known environmental risk factors. One useful research resource would be a ‘healthy
cohort’, a large epidemiologically robust
group of individuals (Box 1) with unusually
good health, who could be compared with
cohorts of individuals with diseases and who
could also be intensively studied to reveal
alleles protective for conditions such as diabetes, cancer, heart disease and Alzheimer’s
disease. Another promising approach would
be rigorous examination of genetic variants
in individuals at high risk for specific diseases who do not develop them, such as
sedentary, obese smokers without heart disease or individuals with HNPCC mutations
who do not develop colon cancer.
Grand Challenge II-3 D e v e l o p g e n o m e b a s e d a p p ro a c h e s t o p r e d i c t i o n o f d i s e a s e
s u s c e p t i b i l i t y a n d d r u g r e s p o n s e , e a rl y
d e t e c t i o n o f ill n e s s , a n d m o l e c u l a r
t a x o n o m y o f d is e a s e st a t e s
The discovery of vari...
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This document was uploaded on 04/02/2014.
- Fall '14
- The Tempest