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Unformatted text preview: ication schemes and
advance both disease prevention and treatment. The reclassification of neuromuscular
diseases32 and certain types of cancer33 provides striking initial examples, but many
more such applications are possible.
Such a molecular taxonomy would be the
basis for the development of better methods
for the early detection of disease, which often
allows more effective and less costly treatments. Genomics and other large-scale
approaches to biology offer the potential for Grand Challenge II-4 U s e n e w
u n d e rs t a n d i n g o f g e n e s a n d p a t h w a y s t o
d e v e l o p p o w e rf u l n e w t h e r a p e u t i c
a p p ro a c h e s t o d i s e a s e
Pharmaceuticals on the market target fewer
than 500 human gene products34. Even
though not all of the 30,000 or so human
protein-coding genes7 will have products
targetable for drug development, this suggests that there is an enormous untapped
pool of human gene-based targets for therapeutic intervention. In addition, the new
understanding of biological pathways provided by genomics (see Grand...
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- Fall '14
- The Tempest