Such a molecular taxonomy would be the basis for the

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Unformatted text preview: ication schemes and advance both disease prevention and treatment. The reclassification of neuromuscular diseases32 and certain types of cancer33 provides striking initial examples, but many more such applications are possible. Such a molecular taxonomy would be the basis for the development of better methods for the early detection of disease, which often allows more effective and less costly treatments. Genomics and other large-scale approaches to biology offer the potential for Grand Challenge II-4 U s e n e w u n d e rs t a n d i n g o f g e n e s a n d p a t h w a y s t o d e v e l o p p o w e rf u l n e w t h e r a p e u t i c a p p ro a c h e s t o d i s e a s e Pharmaceuticals on the market target fewer than 500 human gene products34. Even though not all of the 30,000 or so human protein-coding genes7 will have products targetable for drug development, this suggests that there is an enormous untapped pool of human gene-based targets for therapeutic intervention. In addition, the new understanding of biological pathways provided by genomics (see Grand...
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