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participants in this new form of preventive
medicine (Box 6).
The time is right for a focused effort to
understand, and potentially to reclassify, all
human illnesses on the basis of detailed molecular characterization. Systematic analyses
of somatic mutations, epigenetic modificaNATURE | VOL 422 | 24 APRIL 2003 | www.nature.com/nature developing new tools to detect many diseases
earlier than is currently feasible. Such
‘sentinel’ methods might include analysis of
gene expression in circulating leukocytes,
proteomic analysis of body fluids, and
advanced molecular analysis of tissue biopsies. An example would be the analysis of
gene expression in peripheral blood leukocytes to predict drug response. A focused
effort to use a genomic approach to characterize serum proteins exhaustively in health
and disease might also be highly rewarding. tions, gene expression, protein expression
and protein modification should allow the
definition of a new molecular taxonomy of
illness, which would replace our present,
largely empirical, classif...
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This document was uploaded on 04/02/2014.
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