Systematic analyses of somatic mutations epigenetic

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Unformatted text preview: med participants in this new form of preventive medicine (Box 6). The time is right for a focused effort to understand, and potentially to reclassify, all human illnesses on the basis of detailed molecular characterization. Systematic analyses of somatic mutations, epigenetic modificaNATURE | VOL 422 | 24 APRIL 2003 | developing new tools to detect many diseases earlier than is currently feasible. Such ‘sentinel’ methods might include analysis of gene expression in circulating leukocytes, proteomic analysis of body fluids, and advanced molecular analysis of tissue biopsies. An example would be the analysis of gene expression in peripheral blood leukocytes to predict drug response. A focused effort to use a genomic approach to characterize serum proteins exhaustively in health and disease might also be highly rewarding. tions, gene expression, protein expression and protein modification should allow the definition of a new molecular taxonomy of illness, which would replace our present, largely empirical, classif...
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This document was uploaded on 04/02/2014.

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