Unformatted text preview: of new genetic technologies and information. Translating the
success of the HGP into medical advances
intensifies the need for proactive efforts to
ensure that benefits are maximized and
harms minimized in the many dimensions
of human experience.
A reader’s guide
The vision for genomics research detailed
here is the outcome of almost two years of
intense discussions with hundreds of scientists and members of the public, in more than
a dozen workshops and numerous individual consultations (see www.genome.gov/
About/Planning). The vision is formulated
into three major themes — genomics to biology, genomics to health, and genomics to
society — and six crosscutting elements.
We envisage the themes as three floors
of a building, firmly resting on the foundation of the HGP (Figure 2). For each theme,
we present a series of grand challenges, in the
spirit of the proposals put forward for mathematics by David Hilbert at the turn of the
twentieth century18. These grand challenges
are intended to be bold, amb...
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