collins_genomicsNature2003

Computational infrastructure for housing accessing

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Unformatted text preview: lities, including new approaches for tackling ever-growing and increasingly complex data sets and a suitably robust computational infrastructure for housing, accessing and analysing those data sets (Box 3). In parallel, investigators will need to become increasingly adept in dealing with this treasure trove of new information (Box 4). As a better understanding of genome function is gained, refined computational tools for de novo prediction of the identity and behaviour of functional elements should emerge21. Complementing the computational detection of functional elements will be the generation of additional experimental data by high-throughput methodologies. One example is the production of fulllength complementary DNA (cDNA) sequences (see, for example, mgc.nci.nih.gov and www.fruitfly.org/EST/full.shtml). Major challenges inherent in programmes to discover genes are the experimental identification and validation of alternate splice forms and messenger RNAs expressed in a highly restricted fashion. Even more challenging is the experimental validatio...
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