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Naturecomnature processes in normal and disease

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Unformatted text preview: oning of specific proteins and protein pathways will yield important new insights about physiological NATURE | VOL 422 | 24 APRIL 2003 | www.nature.com/nature processes in normal and disease states. An enhanced ability to incorporate information about genetic variation into human genetic studies would usher in a new era for investigating the genetic bases of human disease and drug response (see Grand Challenge II-1). Grand Challenge I-4 U n d e rs t a n d e v o l u t i o n a r y v a ri a t i o n a c ro s s s p e c i e s a n d t h e m e c h a n i s m s u n d e rl y i n g i t The genome is a dynamic structure, continually subjected to modification by the forces of evolution. The genomic variation seen in humans represents only a small glimpse through the larger window of evolution, where hundreds of millions of years of trialand-error efforts have created today’s bio- sphere of animal, plant and microbial species. A complete elucidation of genome function requires a parallel understanding of the sequence differences across species and the fundamental processes that have sculpted their genomes into the modern-day fo...
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