Esdin LS 2 Lec 7 Endocrine

Or proteins not membrane permeable lipids are

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Unformatted text preview: ormones can be made of steroids or proteins not membrane permeable/ lipids are peptides peptide cannot get inside cytoplasm/ steroid can •  Their synthesis and secretion vary simple diffusion steroid exocytosis peptide •  Their chemical structure determines their mechanisms of action on target need carriers, lipoproteins cells steroid: long-term, lipid soluble, slow acting, intracellular, smooth ER, mitochondria peptides: short-term, made in RER, made of amino acids receptors on the membrane G protein coupled, rapid/short term effect Synthesis of Peptides •  Hormones are synthesized in the ribosomes and RER as preprohormones that get converted to prohormone •  Packaged in Golgi as prohormone 4 4/21/13 Synthesis of Peptides Nucleus Golgi apparatus Rough ER Secretory vesicles Mode of Travel Gland Gland Hormone Blood Peptide hormones Hormone Blood Steroid hormones parathyroid: spine: norepinephrine -> adrenal medulla (kidney) -> fight or flight 5 4/21/13 Mechanisms of Steroids Action on Target Cell bind to DNA regulatory site Nucleus Plasma membrane H H 1 DNA 3 HRE steroid-receptor complex translocates to nucleus transcription R mRNA 2 hormone binds to receptor in cytoplasm 4 protein created mRNA translation Physiological response 6 5 Synthesis of new protein Me...
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This note was uploaded on 04/02/2014 for the course CHEM 14BL taught by Professor Pang during the Summer '07 term at UCLA.

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