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Esdin LS 2 Lec 9 Respiratory

Decreases oxygen afnity for hemoglobin bpg 23

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Unformatted text preview: more ATP What Affect Hb-Oxygen Binding? decreases oxygen affinity for hemoglobin •  BPG (2,3 Bisphosphoglyceric acid) increase in BPG signals that you need more oxygen •  Temperature increase T, increase O •  increase acidity, need more oxygen Acidity when more lactic acid (when we started fermenting) so we need more O more oxygen released in tissue when low partial pressure of oxygen 14 4/21/13 How is Carbon Dioxide Transported? 5-6 % •  Dissolved (___) can't dissolve too much without making blood too acidic 5-8% •  Hemoglobin (___) RBC don't have super high affinity for CO2 86-90% •  Bicarbonate (____) buffer –  CO2 + H2O ⇔ H+ + HCO3- carbonic anhydrase is enzyme needed How is CO2 Transported? carry to lungs Capillary bed Tissue cells Endothelial cells Hb-CO2 CO2 Erythrocyte HCO3- Tissue cells 15 4/21/13 How is CO2 Transported? Alveolus Capillary bed Alveolus CO2 HCO3- Hb-CO2 Endothelial cells Control of Breathing brain initiates all lung activity resp. centers also in pons Inspiratory neurons Medulla oblongata + Spinal cord phrenic nerve + Diaphragm medulla oblongata -> spinal cord -> phrenic nerve -> diaphragm 16 4/21/13 Control of Breathing •  Inspiration is initiated by stimulating the respiratory muscles –  Diaphragm and external intercostals •  The stimulation is initiated in the medullary centers and the pons Chemoreceptors measure O and CO2, brain changes breathing based on this •  Peripheral PNS –  Carotid bodies carotid arteries –  Aortic bodies on the aorta •  Central CNS in the medulla 17 carbon monoxide poisoning: binds to RBCs and doesn't allowed oxygen to bind oxygen that is dissolved isn't that usuable by the cells, not very much so you have dissolved O2, but not O2 on erythrocytes but your body won't notice this, and no panic response will ensue 4/21/13 Peripheral Chemoreceptors Sensory nerve fibers Sensory nerve fibers Carotid bodies Aortic bodies 18...
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