Esdin LS 2 Lec 6 Immune

Increased permeability histamine causes vasodilation

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Unformatted text preview: roteins Sharp object Fluid Blood vessel Interstitial fluid Mast cells Skin 10 4/21/13 Vasodilation & Increased Permeability •  Histamine causes vasodilation –  Increase in blood flow to infected area –  Redness occurs –  Increase delivery of proteins –  Edema occurs •  Proteins gain entry from blood to interstitial fluid Phagocytic Cell Migration Phagocytic cell Blood vessel Interstitial fluid Skin 11 4/21/13 Phagocytic Cell Migration •  The cytokines released by macrophages signal the endothelial cells to express selectin •  Margination occurs •  Phagocytic cells produce integrin on their membrane •  Stronger attachment occurs Phagocytic Cell Migration •  Phagocytic cells begin to move from the blood to the infected area in a process known as ________ •  Once in the interstitial fluid, phagocytic cells are attracted to the site of injury by chemotaxins 12 4/21/13 Phagocytosis Phagosome Lysosome Enzymes Phagolysosome Degradation Exocytosis Phagocytosis 13 4/21/13 Phagocytosis •  Attachment •  Internalization •  Degradation •  Elimination of debris Extracellular Destruction: Complement •  Membrane Attack Complex (MAC) –  Embeds itself in the microbe membrane forming pores –  Water and salt enter the microbe 14 4/21/13 Complement System First complement protein (inactive) Cascade of protein activation Bacterial cell Fluid rushes into cells Pore Pore formation Swelling Lysis 15...
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This test prep was uploaded on 04/02/2014 for the course CHEM 14BL taught by Professor Pang during the Summer '07 term at UCLA.

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