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Unformatted text preview: bile----Gall Bladder-----back into intestine.
each one of the liver cells, get a really good look at everything coming in
the liver also synthesis and excrets bile Liver Secretion
Metabolites will be excreted by active transporters back into
the blood stream OR out with the bile to the gall bladder
If its back into the blood stream will continue to kidneys and
be filtered out into URINE
If secreted to bile, travel to small intestine, excreted with
WHAT DETERMINES WHERE IT WILL GO?? metabolizes and changes compounds, hepatocytes will either pump this back into blood stream
where it eventually gets to kindeys and gets excreted OR down into gall bladder and eliminated
by feces (THIS DEPENDS ON SIZE) expressed on bile side and location and abundance of protein carriers Billiary Excretion
Bile salts are detergents: Emulsify fats (break down large
globules for easier digestion)
Have both lipophilic and hydrophilic character
Therefore the bile environment will easily accommodate lipid
soluble toxicants (un-conjugated) and water soluble conjugates
Ultimate determination is based on size and transporters
Once released from gall bladder into SI
different compartment, can be acted
upon by bacteria, pH, some reabsorption Biliary Secretion
Compounds divided into three categories based on ratio of biliary:
either is gets excreted by bile, or urine or no preference and can go to both A- ratio around 1- glucose, mercury, thallium cesium, sodium
B- ratio greater than 1-bile acids, bilirubin, MANY XENOBIOTICS
C- ratio less than 1- insulin, albumin, zinc, iron, gold Most compounds can
be excreted in both
ways! In general, compounds with MW less than 325Da = poor biliary
excretion, greater than 325Da = good biliary excretion
Glutathione and glucuronide conjugates generally excreted well in the...
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This document was uploaded on 04/07/2014.
- Fall '14