formaldehyde and vinyl acetate forms tumors in rat

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: f fluid (humidify the air) - High surface area, high blood flow, thin membrane - Susceptible to absorption and toxicity! - Formaldehyde and vinyl acetate forms tumors in rat nasal cavities different toxic stuff senstive to corrosive agents, (e.g. HCl) dissolves into aq. mucous, beomces acid 3. Respiratory System: “Pulmonary Route” Lower Airways (alveolus/alveoli) allow for gas exchange (passive diffusion) Protective mechanisms macrophages /phagocytosis of particulate matter/debris (can trap particulate which remains) Function: Gas exchange! High blood flow, thin membrane Also depends on solubility, Small particulate can travel down (SIZE!) Dissolve in fluid, solubility influences Gases diffuse across membrane, dependant on their blood-to-gas partition coefficient Equilibrium dependant High blood flow maintains favorable equilibrium Transporters also present 3. Respiratory System: “Pulmonary Route” Characteristics favouring absorption: A. Single celled lipoidal membrane Type 1 pneumocytes very thin B. Large surface area-expansion of lungs, many aveoli C. Large blood supply (pulmonary circulation) D. Phagocytosis and migration (asbestosis carcinogenesis) Toxicity through the pulmonary route will depend on get down to lower levels of lungs - Particulate size and volatility - Ability to diffuse cross into blood stream - Affinity for transporters protein transporters to carry it away Asbestos Toxicity Small Silicate fibers Good electrical and regular insulation Fire resistant, chemical resistant Good tensile strength Different forms have metals in their composition Mg3(Si2O5)(OH)4 or Fe7Si8O22(OH)2 Asbestos Toxicity Iron on some can produce toxicity through ROS production Fenton reaction Also get ingested by Phagocytic Macrophages Will cross the membrane into the tissues by this method Text Asbestos Toxicity Local inflammation, production of ROS, degredative enzymes Prolonged inflammatory response Cell repair (collagen) and proliferation (scar tissue, function) Asbestosis and possibly Cancer...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern