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General chemical herbicide toxicity 2 lung free

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Unformatted text preview: ity) 2. Lung “Free Radical Generation” Paraquat¯ , 0°¯ (singlet), lipid peroxidation, gets reduced quick by O2 in cells and creates a super ROS NADPH generates Super oxide radicals generation of a lot of Free radical damage (generation of O2-. , .OH) rtoeactive species that cause damage molecules (i.e. DNA, proteins etc) causes cell death H3C N N CH3 +e- H3C paraquat NADPH NADP+ N N paraquat cation radical fpox fpred PQ O2 PQ +2 REDOX CYCLING - O2 CH3 Pathogenesis 2.) Delayed phase (3-8 days) Type I Alveolar fluid (top picture) Cells “damaged” free radical damage! cells die and release body then responds by repairing cells then scar tissue forms Congestion and Edema Hyline Membrane Formation 3) Chronic Phase (8 days) Diffuse Fibrosis Healing scar tissue means gas exchange efficieny is impacted negatively Hyline Membrane formation Pathogenesis Epithelialization body tries to heal itself Fibrosis and Consolidation complete loss of function of lung tissue because diffusion tissue is not as good lung specific because cation transporter brings them to lung, where it is stored because there is no other transporter to take them out Treatments Fullers Earth (bentonite) Bind cations Acute: - Vit E, C, Selenium (anti-oxidants) - steroids - mucomyst “Acetylcysteine” – SH Chronic: - supportive - grave prognosis - lung transplant treatments give something that will bind to compound so it will get digested...
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