Urine diabetes diabetes insipidus diabetes mellitus

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Unformatted text preview: insipidus Diabetes mellitus have to pee a lot ‘a siphon’ - polyuria diabetes part mellitus - ‘sweetened with honey’ clinical sign of diabetes is polyuria early diabetes test dip finger in urine and sip with tongue if insipid - no taste then insipid if sweet then mellitus amount of insulin or activity of insulin problem in Type I amount destruction or way it works in cells (connection with receptors) Type 1 Diabetes mellitus Islet Cell Loss Autoimmunity (T cell mediated) Many have autoantibodies too Genetic predisposition Environmental factors Precipitating event fatty tissue is largest endocrine gland in body Type 2 Diabetes mellitus related to hyperglycemia Strong genetic link Obesity link (abdominal fat) abdominal fat is the worse when it comes to diabetes Adipokine dysregulation Leptins – satiety hormone - increase with increased adipose tissue Adiponectins – decrease with increased adipose tissue Protects from insulin resistance (stimulates insulin sensitivity) Inhibits atherosclerosis C-reactive protein (CRP)/(IL-6) link acute phase protein - systemic response to inflammation heightened inflammatory response with increased adipose Resistin Type 2 Diabetes mellitus Peripheral insulin resistance body becomes resistant to insulin stops tissue from taking up glucose and blood glucose remains high Receptor downregulation Post receptor signaling inhibited Deranged Beta-cell secretion Beta-cells less responsive to glucose Initial compensation then Less...
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