Bone diet age reproductive state tness three big

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Unformatted text preview: diet, age, reproductive state, fitness three big reasons for bone not to be there in right amount to increase amount of bone, use bone i.e., weight lifting to increase bone strength i.e., putting stress on bone same thing that increase bone mass increase muscle mass activity Disuse atrophy reduceuse it you lose it don’t when women go through menopause Gonadal insufficiency when estrogen level gets low aging Senility hard to separate 3 effects from each other animal with osteoporosis provides support taking away of bone area where bone usually decreases first osteum = unit of bone small holes is where primary bone cell (osteocyte) is present clear area on sides is fat (part of bone marrow) multi-nucleated giant cells - exivates bone (pac-man) - actively removing bone - dirved from macrophages - similar to granuloma releases enzymes on bone, and they dissolve bone Osteoblast osteocytes 3 main cells that influence bone Histology of bone Remodeling – productionlayand resorption down bone produce colagen required Osteoblasts - production produce substances required for minerals to be acquired and lay on bone bone Osteocytes - osteolysis dissolve this to a large extent can’t do Osteoclasts - macrophages osteoblasts osteoclasts osteocytes Metabolism can make bone anywhere in bond need oxygen, compression and proper cell type gland beside thyroid - removes calcium from bone Parathormone - parathyroid gland hormone that stores calcium Calcitonin - thyroid gland Vitamin D - food, skin, liver and kidney Cytokines -activity Interleukin 1, TNF beta influence osteoclast comes from food - one part goes to skin and UV radiation acts on it, metabolism in liver assist uptake of calcium from intestine helps resist infection Osteoporosis as bone is removed it cannot be replaced Non mechanical or permissive factors Dietary calcium, vit D, aminoproduce collagen acids to Mechanical factors have good bone mass everywhere except for spine swimmers Muscle strength weight lifting is the best option for bone mass A 75 year old has half the bone of a 20-30 year old. A...
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This note was uploaded on 04/07/2014 for the course PATH 3610 taught by Professor Foster during the Winter '07 term at University of Guelph.

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