151.L1.Lect7.Kidney.11.22.13.Stu

High osmolarity in blood stimulates release of anti

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Unformatted text preview: ressure) or if high salt conc. (high osmolarity) in blood: - stimulates release of anti-diuretic hormone (ADH) stimulates from the posterior pituitary into blood from - ADH binding to receptors in epithelial cells of distal tubule induces expression of aquaporin-2 water tubule transporters transporters - water can now follow salt out of filtrate and counteracts low volume or high osmolarity osmolarity Collecting Duct: loses water when blood volume low, Collecting osmolarity high (loses salt, ignore) (loses (units in mOsm/L) The greater the mOsm/L value, the more salt/urea concentrated the fluid: - in extracellular fluid when indicated outside nephron - in filtrate when indicated inside nephron Campbell Figures 44.15-16 Collecting Duct: loses water when blood volume low, Collecting osmolarity high (loses salt, ignore) (loses (units in mOsm/L) In epithelial cell membranes: - high density of aquaporin-2 (ADH dependent) - water moves out only when ADH elevated in blood - FURTHER REDUCE VOLUME OF FILTRATE The greater the mOsm/L value, the more salt/urea concentrated the fluid: - in extracellular fluid when indicated outside nephron - in filtrate when indicated inside nephr...
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