Lecture 6

19 modifying nucleosomes through methylated dna dna

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: etween methylation and gene activity Figure 2.19 Modifying nucleosomes through methylated DNA DNA methylation can block transcription by preventing transcription factors from binding to the enhancer region (HDAC) Methylation of cytosine residues around genes helps maintenance of transcription patterns Figure 2.20 Two DNA methyltransferases are critically important in modifying DNA 3 1/31/13 Epigenetic Regulated Events in Mammalian Cells •  Epigenetic drift •  Genomic imprinting •  X-inactivation Nature Reviews Genetics 2012 Feb (13) 97-109, R. Feil and M. Fraga LQ! Agouti mice •  Agouti gene: encodes paracrine signaling fa...
View Full Document

This document was uploaded on 04/03/2014.

Ask a homework question - tutors are online