Lecture 6

Neural restrictive silencer element nrsf neural

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: (white) Silencers influence Transcription NRSE: neural restrictive silencer element NRSF: neural restrictive silencer factor (expressed in all cells except mature neurons) Changes in gene expression & chromatin compaction that do not involve a change in the nucleotide sequence of DNA Epigenetic Regulation of Transcription Cytosine DNA MethylaSon The 5th base: 5% cytosines  5-meC at CpG islands 1. Cytosine DNA Methylation 2. Histone Modifications 3. microRNAs H H Each mechanism can affect the structure and/or conformation of chromatin .and thus influence transcriptional activity CpG islands found in 50% all promoters! 2 1/31/13 Correlation b...
View Full Document

This document was uploaded on 04/03/2014.

Ask a homework question - tutors are online