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Lecture 7 - Xchromosomes in Mammals and drosophila...

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2/5/13 1 'SPN /BUVSF 3FWJFXT (FOFUJDT ±²²³ "QSJM ´µ¶ ±·¸¹±º± 3» +JSUMF BOE .» 4LJOOFS (FOPNF XJEF EF BOE SFNFUIZMBUJPO 4QFDJGJDBMMZ *.13*/5&% HFOFT ´NFUIZMBUJPO NBSLT PO TFMFDU HFOFT¶ BSF /05 EJTUVSCFE %PTBHF DPNQFOTBUJPO JT BDIJFWFE JO EJGGFSFOU XBZT JO EJGGFSFOU PSHBOJTNT X-chromosomes in Mammals and drosophila 9¹DISPNPTPNF JOBDUJWBUJPO JO UIF NPVTF FQJUIFMJBM DFMM OPSNBM GFNBMF FQJUIFMJBM DFMM 999 GFNBMF MBD; PO NBMF 9 E¼½ CPUI 9 BDUJWF Eº½ JOBDUJWBUJPO #BSS #PEJFT TFFO BU UIF OVDMFBS FOWFMPQF .FDIBOJTN PG 9¹JOBDUJWBUJPO JO .BNNBMT½ $PNQMJDBUFE¾ ¹ NFUIZMBUJPO PG QSPNPUFS %/" JO JOBDU 9 WT» BDUJWF 9» ¹ )JTUPOF IZQPBDFUZM`O BOE NFUIZMBUJPO PO JOBDUJWF 9» Nucleus Chromatin (DNA-protein complex) 1. Chromatin remodeling 2. Transcription l Open z DNA (Some DNA not closely bound to proteins) 3. RNA processing Primary transcript (pre-mRNA) Cap Tail Mature mRNA Cytoplasm 4. mRNA stability 5. Translation Degraded mRNA (mRNA lifespan varies) mRNA Polypeptide Active protein 6. Post-translational modification (folding, transport, activation, degradation of protein)
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