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Final Exam Solution

For polyglutamic acid below ph 4 the sidechain

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Unformatted text preview: onation at sidechains) is stabilized oints/drawing for not indicating while of side groups lower pH to NH3+ will favor the-­‐2.5 points/drawing for not showing reasonable intramolecular forces more extended "random" conformation. In both cases, electrostatic repulsion between charged sidechains destabilizes the helical conformation. For polyglutamic acid below pH 4, the sidechain carboxyl groups are protonated (neutral), while at high pH they are ionized to the carboxylate and negatively charged. (10 points) Charge repulsion ("random" s used in the sense inimized by t a helix c secondary structure. xtended ("random") between the isidechains will be mof not havinghe regularonverting to a more eThere could be some confusion chain conformation w analysis where the most random state was the most compact polypeptide with the rubber band hich will increase the average separation between sidechains state; in the current problem, the repulsion. and hence reduce the electrostatic resulting structure with ionized sidechains will not be the most compact structure but will be a more extended structure (to minimize charge repulsion) and the polypeptide chain will not have repeating phi,psi angles - this is often loosely referred to Electrostatic repulsion between charged sidechains destabilizes the helical conformation. (10 as a "random ome form of charge/electrostatic repulsion.) points for scoil" conformation) ("random" is used in the sense of not having a regular secondary structure.) c + 10 −2 ΔG = RT ln H , stomach = 0.0083144 × 310 × ln −7 = +29.7 kJ mol−1 6. cH + ,cell 10...
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