be230cLecture8

B and c electrical acgvagon pahern as obtained with

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Unformatted text preview: ght © American Heart Association Figure 2. Development of chambers and ECG. A, Left-sided view of embryonic hearts of embryonic day (E) 8 to 8.5 and E9.5 to 10.5, respectively. Christoffels V M , and Moorman A F Circ Arrhythm Electrophysiol 2009;2:195-207 Copyright © American Heart Association Electrophysiological Changes in Pacemaker FuncGon During Development During development, iniGally the enGre sinus venosus myocardium is capable of generaGng the iniGal electrical acGvaGon. Later in development the right sided SAN will become the definiGve pacemaker. (a) RepresentaGve example of an ex ovo electrophysiological recording of an embryonic chick heart (stage HH21), demonstraGng lef atrial acGvaGon (LAc) preceding the right atrial acGvaGon (RAc) with 4,6 ms. (b) and (c) Electrical acGvaGon pahern as obtained with opGcal mapping, dorsal view, showing the iniGaGon of the electrical signal (indicated in red) in the LA. d. RepresentaGve example of an ex ovo electrophysiological recording of an embryonic chick heart (stage HH29), demonstraGng RA acGvaGon preceding the LA acGvaGon with 3,1 ms. (e) and (f): Electrical acGvaGon pahern as obtained with opGcal mapping, dorsal view, showing the iniGaGon of the electrical signal (indicated in red) in the RA. AbbreviaGons: SV: sinus venosus, OFT: ouolow tract, V: ventricle. 7 4/25/13 Progressive ContracGle and ConducGve MaturaGon during Cardiogenesis Lineage RelaGonship Between the Working and ConducGng Myocytes •  •  Lineage labelling in transgenic mice by random acGvaGon...
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This document was uploaded on 04/09/2014.

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