be230cLecture4

D et al science 298 21882190 2002 raya a et al pnas

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Unformatted text preview: bal Pulse ­Chase Experiment Cardiomyoyctes turn over at an annual rate of 1 percent at age 25, slowing to about 0.45 percent by age 75 Pulse (1945 ­1963) Chase (1963 ­present) Bergmann, O.et al., Science 324: 98 ­102 (2009). 5 4/10/13 Where Do New Heart Muscle Cells Come From? Pre ­exis/ng cardiomyocytes •  New cardiomyocytes for heart regeneraAon might come from three sources: –  pre ­exisAng cardiomyocytes, –  endogenous progenitors, or –  exogenous progenitors (e.g. bone marrow) •  Lineage labelling studies are done to discriminate these possibiliAes Scarless Heart RegeneraAon in Zebrafish Poss, K.D et al., Science 298: 2188 ­2190 (2002). Raya, A. et al., PNAS 100 Suppl 1: 11889 ­11895 (2003). Lepilina, A. et al. Cell 127: 607 ­619 (2006). In Adult Zebrafish, RegeneraAon Occurs by ReplicaAon of Pre ­exisAng Cardiomyocytes, Not From Stem or Progenitor Cells Jopling, C., et al., 2010. Nature 464(7288): 606 ­609. Kikuchi, K. et al., 2010. Nature 464(7288): 601 ­605. 6 4/10/13 In Adult Mice, Most New Cardiomyocytes Come from Progenitors, Not Pre ­exisAng Cardiomyocytes Hsieh, P.C.et al., 2007. Nature medicine 13(8): 970 ­974 Heart RegeneraAon in Fish and Mammals Mouse Zebrafish •  Modest level of regeneraAon in the mouse heart aRer injury •...
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