be230cLecture4

No evidence for cardiomyocytes undergoing mitosis

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Unformatted text preview: . Circula5on research 83(1): 15 ­26. 2 4/10/13 Origin of the Concept that the Heart is Non ­RegeneraAve   No increase in number of nuclei in hypertrophic heart, although atrophic heart has an increase in nuclei.   No evidence for cardiomyocytes undergoing mitosis.   Whether the elevated number of nuclei in atrophic Assue is a sign of regeneraAon is unclear since non ­ cardiomyocytes might account for the increased nuclear count. Karsner et al. The American Journal of Pathology 1, 351 ­372 351 (1925). Zak, et al., The American Journal of Cardiology 31(2): 211 ­219 (1973). Classical View of Heart FuncAon Galen of Pergamon (129 ­~200) is credited with the view that blood is conAnuously being generated, and converted into flesh in a one ­way process from liver to heart to extremiAes It took 1500 years to alter this view!!! Anatomists in the late 15th and 16th centuries began to quesAon the unidirecAonal flow of blood Leonardo da Vinci, 1452 ­1519 3 4/10/13 Anatomists in the late 15th and 16th centuries began to quesAon the unidirecAonal flow of blood Andreas Vesalius, 1543, De Humani Corporus Fabrica (On the Fabric of the Human Body) William Harvey and ExperimentaAon Revealed Circulatory Blood Flow Does the Human Heart Regenerate?...
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