be230cLecture7

1 42313 formalon of the linear heart tube by the 3rd

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Unformatted text preview:   By the 3rd week, the heart field cells have coalesced into two angioblasLc cords that eventually form the linear heart tube on the ventral side of the embryo (next 3 slides). 1 4/23/13 FormaLon of the Linear Heart Tube •  By the 3rd week, the heart field cells have coalesced into two angioblasLc cords •  An endothelial lining forms, derived most likely from the heart field and from extra ­cardiac endothelial cells that migrate into the developing tube •  The cords merge anterioposteriorly to form the linear heart tube by about 21 days Cross SecLon Views Show Lateral Folding •  Linear heart tube forms in the pericardiac cavity •  Note the gut tube closing •  Heart tube is connected to the dorsal pericardium by the dorsal mesocardium; this will eventually degenerate forming the transverse sinus of the pericardium Second Heart Field •  Primary heart field gives rise to LF and porLon of the atria •  Second heart field, marked by disLnct gene and reporter construct (in mice) expression profile, gives rise to RV, OT, SV and part of the atria. 2 4/23/13 Development of the Heart from First and Second Heart Fields Linear Heart Tube •  Derived from heart field •  Will undergo looping, chamber and valve morphogenesis, as well as...
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This document was uploaded on 04/09/2014.

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