be230cLecture7

2 tbx1 encodes a transcriplon factor expressed near

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Unformatted text preview: include mutaLons in: –  Jagged ­1 –  Nkx2.5 –  Vascular endothelial growth factor (VEGF) hep://www.youtube.com/watch?feature=player_embedded&v=PRxN6migkW8 ContribuLon of the Neural Crest •  •  •  •  •  Cardiac neural crest cells emigrate from the dorsal neural tube at the level of the hindbrain, more specifically between the midoLc placode and the caudal limit of the third somite CNCCs migrate beneath the ectoderm into the circumpharyngeal area where they enter the 3 posterior pharyngeal arches. They condense around the aorLc arch arteries, and some conLnue into the cardiac ouRlow tract In the ouRlow tract, CNCCs contribute to cardiac ganglia and mesenchyme at the juncLon of the subaorLc and sub pulmonary myocardium (eventually muscular heart Lssue) of the ouRlow tract. Some CNCCs migrate enter the proximal ouRlow tract where they help to close the ventricular ouRlow septum. Failure of CNCC migraLon or funcLon might underlie many OFT malformaLons 12 4/23/13 DiGeorge Sy...
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