be230cLecture7

5 tbx5 holtoram syndrome hos an autosomal dominant

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: extends from the cushion •  Permits oxygen ­rich blood to pass from right to led •  Septum secundum, a thick muscular membrane descends from roof of atrium 7 4/23/13 Atrial SeptaLon – Foramen ovale •  Septum secundum conLnues to develop •  Foramen ovale allows oxygenated blood to flow from RA to LA, higher pressure in RA. •  Foramen ovale valve closes ader birth as pressure in LA increases as pulmonary circulaLon increases Atrial Septal Defects •  Various types –  OsLum secundum (most common)/ patent foramen ovale –  Endocardial cushion defect –  Sinus venosus defect –  Common atrium Genes Associated with Human Congenital Atrial Septal Defects •  Nkx2.5 •  Tbx5 [Holt ­Oram syndrome (HOS), an autosomal, dominant, highly penetrant disorder associated with malformaLons of the upper limb and congenital heart disease, most commonly ASD or ventricular septal defect (VSD)] •  GATA4 •  TBX20 Severe Atrial Septum Normal Secundum Defect (ASDII) Posch et al., Clin Res Cardiol. 2010 8 4/23/13 Ventricular SeptaLon •  •  Muscular interventricular septum (IVS) divides common ventricle IV foramen closes by the end of the 7th week Balooning and TrabeculaLon of Ventricular Walls •  •  Spongy muscular Lssue (Trabeculae) Bundles of mu...
View Full Document

Ask a homework question - tutors are online