And truncal ridges form in the ourlow tract fusion of

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Unformatted text preview: scle become the papillary muscles and tendinous cords that are aeached to the cusps of the tricuspid and mitral (R and L AV valves 5 weeks 6 weeks 7 weeks 20 weeks Ventricular Septal Defects •  Membranous VSD –  Most common –  Failure to form membranous part of IVS –  Large VSDs •  Muscular VSD –  Missing part of muscular IVS –  Image has transposiLon of great arteries •  Mixing of arterial and venous blood •  ComplicaLons include excessive pulmonary blood flow and hypertension, dyspnea (difficulty in breathing) and heart failure 9 4/23/13 Development of the Atrioventricular Valves •  •  ProliferaLon of subendocardial Lssue around AV canals, 5th to 6 weeks CompleLon of valve development, 7 weeks, and connecLon to papillary muscles and tendinous chords 5 weeks 6 weeks 7 weeks 20 weeks Development of the AorLc and Pulmonary (Semilunar) Valves •  •  •  Bulbar and truncal ridges form in the ouRlow tract Fusion of the bulbar ridges separates aorLc and pulmonary ouRlow The semilunar valve cusps form as the ridges thin Epithelial ­to ­mesenchymal transformaLon and valve elongaLon. Lin C et al. Development 2012;139:3277-3299 10 4/23/13 Bicuspid AorLc Valve Defect Modality: Anatomic specimen OrientaLon: Arterial view of the aorta Descri...
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