be230cLecture9

32 95 susceptibility to catecholamine induced

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Unformatted text preview: ia and that betaBase-line demographic data including the New York Heart As1.08 to 1.62; P<0.01), death or hospitalization for heart blockade attenuated this phenotype. sociation (NYHA) functional class and information on the medfailure (relative risk, 1.30; 95 percent confidence inical history and current use of medications were obtained from all terval, 1.11 to 1.53; P<0.005), and death from pump CONCLUSIONS patients at the time of enrollment. Data on race and ethnic backfailure (relative risk, 1.37; 95 percent confidence interground were obtained from the SOLVD eligibility We generated patient-specific pluripotent stem cells from members of a family af- form, on which val, 1.07 to 1.75; P<0.05). The presence of a third heart the ethnic and racial categories were American Indian, Asian, black, sound was associated by long-QT syndrome type 1 and induced them to differentiatethe time of enrollment, investigators fected with similarly increased risks white, Hispanic, and other. At into functional of these outcomes. cardiac myocytes. The patient-derived cells recapitulatedfor theelectrophysiological elevated jugular evaluated patients the presence or absence of n patients with heart failure, elevatConclusions Ifeatures of the disorder. (Funded by the European ResearchaCouncil and others.) basis of a routine venous pressure and third heart sound on the ed jugular venous pressure and a third heart sound physical examination. On separate lines of the SOLVD base-line visit form completed at the time of enrollment, the presence of elare each independently associated with adverse out1 10.1056/nejm evated jugular venous pressure or a third heart sound was indicated comes, including progression of heart failure. As-oa0908679 nejm.org in a “yes” or “no” format. sessment for these findings is clinically meaningful. Downloaded 21, 2010 For personal use (N Engl J Med 2001; 345:574-81.) from www.nejm.org on JulyDefinition. of End Points only. No other uses without permission. Copy...
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