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tic skills. the study gene. We obtained nical University of Munich, Munich, Gerelevated jugularsomal dominant missense mutation (R190Q) in Our KCNQ1tested the hypothesis that the find- reprint requests to Dr.
venous pressure or a third heart
ing of elevated jugular venous pressure or a at the
sound in patients with heart failure is not well estabdermal fibroblasts from two family members and two healthy controls and infected Laugwitzthird Cardiology Division, First
heart sound (also called S3 gallop) on physical examthem with retroviral vectors encoding the human transcription factors OCT3/4, Department of Medicine and German
Methods We performed a retrospective generate pluripotent stem cells. With the use of a specific independentMunich, Klinikum rechts
ination would provide important and Heart Center
SOX2, KLF4, and c-MYC to
der Isar, Technical University of Munich,
the Studies of Left Ventricular Dysfunction treatment
protocol, these cells were then directed prognostic information in patients with heart failure. 22, D-81675 Munich,
trial, in which 2569 patients with symptomatic heart to differentiate into cardiac myocytes.
Germany, or at [email protected]
failure or a history of it were randomly assigned to
RESULTS receive enalapril or placebo. The mean (±SD) followThe Studies of Left Ventricular Dysfunction (SOLVD) treatment
up was 32±15 months. The presence of elevated jugInduced pluripotent stem cells maintained the disease genotype of long-QT syn-total ofMoretti, Bellin, and Welling contribtrial has been described in detail previously.8,9 A Drs. 2569 paular venous pressure or a third heart sound functional myocytes. Individual cells showed a failure or uted equally to this article.
tients with symptomatic congestive heart “ven- a history of it
drome type 1 and generated was ascertained by physical examination on entry into the
tricular,” “atrial,” or “nodal” phenotype, and evidenced to receive expression placebo. Patientswere (10.1056/NEJMoa0908679) was
as a left ventricularthe enalapril or of 0...
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- Fall '14
- cells, Induced pluripotent stem cell, iPS cells, long qt