be230cLecture9

H all at the techsyndrome type 1 identified an auto

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Unformatted text preview: nostic tic skills. the study gene. We obtained nical University of Munich, Munich, Gerelevated jugularsomal dominant missense mutation (R190Q) in Our KCNQ1tested the hypothesis that the find- reprint requests to Dr. venous pressure or a third heart many. Address ing of elevated jugular venous pressure or a at the sound in patients with heart failure is not well estabdermal fibroblasts from two family members and two healthy controls and infected Laugwitzthird Cardiology Division, First lished. heart sound (also called S3 gallop) on physical examthem with retroviral vectors encoding the human transcription factors OCT3/4, Department of Medicine and German Methods We performed a retrospective generate pluripotent stem cells. With the use of a specific independentMunich, Klinikum rechts analysis of ination would provide important and Heart Center SOX2, KLF4, and c-MYC to der Isar, Technical University of Munich, the Studies of Left Ventricular Dysfunction treatment protocol, these cells were then directed prognostic information in patients with heart failure. 22, D-81675 Munich, Ismaninger Str., trial, in which 2569 patients with symptomatic heart to differentiate into cardiac myocytes. Germany, or at klaugwitz@med1.med failure or a history of it were randomly assigned to M ETHODS .tum.de. RESULTS receive enalapril or placebo. The mean (±SD) followThe Studies of Left Ventricular Dysfunction (SOLVD) treatment up was 32±15 months. The presence of elevated jugInduced pluripotent stem cells maintained the disease genotype of long-QT syn-total ofMoretti, Bellin, and Welling contribtrial has been described in detail previously.8,9 A Drs. 2569 paular venous pressure or a third heart sound functional myocytes. Individual cells showed a failure or uted equally to this article. tients with symptomatic congestive heart “ven- a history of it drome type 1 and generated was ascertained by physical examination on entry into the tricular,” “atrial,” or “nodal” phenotype, and evidenced to receive expression placebo. Patientswere (10.1056/NEJMoa0908679) was as a left ventricularthe enalapril or of 0...
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