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Unformatted text preview: .35 or This article ranby ejection fraction of cell- less were endomly assigned trial. The risks of hospitalization for heart failure and type–specific defined by as seen in rolled from the action March 1989. A single published on July progression of heart failure asmarkers anddeath from recordings of June 1986 to potentials in prerandomization run-in 21, 2010, at NEJM.org. phase consisted prolonged in active-drug phase cells. composite end point of potential was markedly of a single-blind “ventricular” (2 to 7 days) pump failure and the The duration of the action death Med followed by or hospitalization for heart failure were compared in with long-QT a placebo run-in phase (14 to 17 days). Patients with and “atrial” cells derived from patients syndrome type 1, as compared N Engl J© 20102010. Copyright Massachusetts Medical Society. worsening heart failure during this phase were excluded from the patients with these findings on control subjects. Further characterization of the role of the R190Q– physical examination with cells from trial. Treatment was initiated predominantly in the outpatient setand patients without these findings. ting (in syndrome cases). revealed a domKCNQ1 mutation in the pathogenesis of long-QT99 percent of type 1The participants were followed for an Results In multivariate analyses that were adjustaverage inant of the severity of heart failure, negative trafficking defect associated with(±SD) to 32±15reduction in IKs protocol was approved a 70 of 80% months. The study cured for other markers by the appropriate review boards of the participating centers, and rent and pressure was activation deactivation consent was Moreover, we elevated jugular venous altered channel associated andwritten informed properties.obtained from the patients. showed hospitalization for heart failwith an increased risk ofthat myocytes derived from patients with long-QT syndrome type 1 had an Data Collection and Definitions ure (relative risk,increasedpercent confidence interval, 1.32; 95 susceptibility to catecholamine-induced tachyarrhythm...
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