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be230cLecture11

circ cardiovasc gen2010 7 5713 heart failure

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Unformatted text preview: diomyopathy (Song et al., CirculaBon 2006) •  1q42 ­43 associated with right ventricular cardiomyopathy, arrhythmia and sudden death that mapped to the RYR2 gene (Rampazzo et al., Hum. Mol. Genet., 1995; Tiso et al., Hum. Mol. Genet., 2001). •  Angiotensin ­converBng enzyme DD genotype in paBents with ischemic or idiopathic dilated cardiomyopathy (Raynolds et al., Lancet, 1993; Andersson et al., J. Am. Coll. Cardiol. 1996) •  beta(1) ­adrenergic receptor polymorphism associated with survival in heart failure (Borjesson et al., Eur. Heart J. 2000). Heart Failure  ­ GWAS •  •  Larson et al., BMC Med. Genet. Supplement 2007 tested about 5000 men and 5000 offspring from Framingham study, failing to find any genes that passed p ­value criterion of 4.4 × 10 ­8 appropriate for the mulBple comparisons performed in the analyses. Relaxing stringency idenBfied 10q25.3 KIAA1598 mapping to RPL5P27, ribosomal protein L5 pseudogene 27 of no clear funcBon. CHARGE consorBum idenBfied a single locus each in European and African ethnic cohorts at the pre ­specified genome wide significance of 5x10 ­7. In the European subset the locus was at 15q22 near USP3...
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