be230cLecture11

Genet 2001 angiotensinconverbng enzyme dd genotype in

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Unformatted text preview: idenBfied in European populaBons. Although the 9p21.3 locus has been replicated in Asian and in African American populaBons, it is important to assess the generalizability of results for the CAD/MI suscepBbility loci in other populaBons. Genes mapped to CAD/MI suscepBbility loci show significant enrichment in lipoprotein metabolism, including genes such as LDLR, LPA, PCSK9, PEMT, and the nearest genes to the 11q23.3 locus (APOA1, APOA5, and APOC3) 6 5/7/13 Interactions between genes mapped to coronary artery disease (CAD)/myocardial infarction (MI) susceptibility loci. Maouche S , and Schunkert H Arterioscler Thromb Vasc Biol 2012;32:170-181 Copyright © American Heart Association Heart Failure – Linkage Studies •  10q25 ­q26.13, cardiomyopathy, diffuse myocardial fibrosis and sudden death (Ellinor et al., J. Am. Coll. Cardiol. 2006) •  7p21 ­7q21, let ventricular hypertrophy, dilataBon, heart failure and sudden cardiac death without the myocyte disarray characterisBc of classical hypertrophic car...
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This document was uploaded on 04/09/2014.

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