be230cLecture11

Rather most loci harbor genes that have not been

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Unformatted text preview: oes not contain any known protein ­coding genes. DeleBon of the orthologous 70 ­kb non ­coding interval on mouse chromosome4 affects cardiac expression of neighboring genes, as well as proliferaBon properBes of vascular cells. Cardiac expression of two genes near the non ­ coding interval, Cdkn2a and Cdkn2b, is severely reduced Primary cultures of Cdkn2a ­ or Cdkn2b ­ deficient fibroblasts and Cdkn2a ­deficient aSMCs show increased proliferaBon rates Mechanism might be a long ­non ­coding RNA in the risk interval that controls expression of CDKN2a and CDKN2b 5 5/7/13 Post–genome-wide association study (GWAS) strategies, and biological and clinical implications of GWAS findings. Maouche S , and Schunkert H Arterioscler Thromb Vasc Biol 2012;32:170-181 Copyright © American Heart Association Results of a Decade of CAD/MI GWAS •  •  •  •  •  •  •  Only a minority cover previously known CAD candidate g...
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This document was uploaded on 04/09/2014.

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