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The cadassociated single nucleobde polymorphisms snps

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Unformatted text preview: 4 5/7/13 Genome ­wide AssociaBon Studies for Cardiovascular Disease •  What is GWAS? •  Coronary Artery Disease(CAD)/myocardial infarcBon (MI) GWAS •  Heart failure GWAS •  Electrocardiography GWAS Overview of CAD/MI SuscepBbility Genes, Example: 9p21.3 •  •  •  •  •  •  9p21.3 locus idenBfied in 2007. Most robustly replicated CAD suscepBbility gene across many studies comprising diverse cohorts. 20% and 25% of Caucasians are homozygous for risk alleles, resulBng in esBmates of 10–31% populaBon aTributable risk. The CAD ­associated single nucleoBde polymorphisms (SNPs) are located within a 58 ­kb linkage disequilibrium block on chromosome 9p21.3 that does not contain any known protein ­coding genes. DeleBon of the orthologous 70 ­kb non ­coding interval on mouse chromosome4 affects cardiac expression of neighboring genes, as well as proliferaBon...
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