G 1 and with a modest relabve risk eg odds rabo of

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: uscepBbility genes, TCF7L2, has odds raBo of 1.025! Combined, these could account for a large proporBon of disease (but how to test combinaBons of many genes or know which combinaBons are important???). In addiBon, there might be alleles of fairly low frequency (e.g. ~ 1%) and with a modest relaBve risk (e.g. odds raBo of ~3) would be hard to detect given either linkage or GWA studies. McCarthy Nature Reviews GeneBcs, 9: 356 (2008) Types of polymorphisms 1. Copy Number Varia=on (CNV) Segment of DNA that are found in different numbers of copies among individuals •  SubstanBal regions, not single nucleoBdes •  A B A C A B C B B C Types of polymorphisms 2.  Single NucleoBde Polymorphism (SNP) 3 5/7/13 Affymetrix Genotyping Chip GWAS to Gene •  •  •  Because GWAS directly genotype only a small proporBon of the variants that segregate within the populaBon exam...
View Full Document

This document was uploaded on 04/09/2014.

Ask a homework question - tutors are online