To diagnose likely infecting organisms in blood and

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Unformatted text preview: oblems Lisp source code for Tmycin can be found at: http://www.cs.cmu.edu/afs/cs/project/ai-repository/ai/areas/reasonng/medical/tmycin/0.html CIS 350 Lecture 7 © Roxanne Hiltz and Eli Rohn 26 13 Spring 2000 - Lecture 7 Why MYCIN? ❚ To diagnose likely infecting organisms in blood and meningitis infections ❚ Uses test results plus information about patient supplied by the doctor CIS 350 Lecture 7 27 Why MYCIN? ❚ Prescribe an effective antibiotic treatment, early in the course of a disease, before all possible information is available ❚ To counteract: ❙ Overuse of antibiotics ❙ Irrational use of antibiotics ❙ Maldistribution of expertise CIS 350 Lecture 7 © Roxanne Hiltz and Eli Rohn 28 14 Spring 2000 - Lecture 7 MYCIN'S Knowledge Base ❚ About 400 diagnostic rules ❚ About 50 therapy rules CIS 350 Lecture 7 29 MYCIN: Example Of Diagnosis Rule (1) IF THE SITE OF THE CULTURE IS BLOOD [AND] THE GRAM STAIN OF THE ORGANISM IS GRAMNEG [AND] THE MORPHOLOGY OF THE ORGANISM IS ROD [AND] THE PATIENT IS A COMPROMISED HOST CIS 350 Lecture 7 © Roxanne Hiltz and Eli Rohn 30 15 Spring 2000 - Lecture 7 MYCIN: Example Of Diagnosis Rule (2) ❚ THEN THERE IS SUGGESTIVE EVIDENCE (0.6) THAT THE IDENTITY OF THE ORGANISM IS PSEUDOMONASAERUGONOSA. CIS 350 Lecture 7 31 MYCIN: Diagnosis Rules: ❚ Use "backward chaining" heuristic: ❚ This means it tries a particular diagnosis and then checks to see if the conditions that support it are present ❚ Reports/chooses the diagnoses with the highest supporting evidence, reporting in terms of probabilities CIS 350 Lecture 7 © Roxanne Hiltz and Eli Rohn 32 16 Spring 2000 - Lecture 7 MYCIN: Therapy Selection Rules ❚ If you are considering giving , , and the patient is less than 1 week old ❚ Then it is definite (1.0) that is contra-indicated for this patient ❚ Justification: newborn infants may develop vasomuscular collapse due to an immaturity of the liver and kidney functions... CIS 350 Lecture 7 33 How MYCIN Looks To The User: Therapy Recommendation ❚ [REC 1] the preferred therapy recommendation is as follows: ❙ In order to cover for items <1 2 3 4 5 > ❘ GIVE THE FOLLOWING IN COMBINATION: 1...
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