Lecture18-M50,51

Understanding schizophrenia are there biological risk

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Unformatted text preview: rs help to explain paranoia and hallucina0ons; it’s like taking amphetamine overdoses all the 0me. Poor coordina0on of neural firing in the frontal lobes impairs judgment and self ­control. The thalamus fires during hallucina0ons as if real sensa0ons were being received. There is general shrinking of many brain areas and connec0ons between them. Understanding Schizophrenia Are there biological risk factors affec0ng early development? Biological Risk Factors Schizophrenia is somewhat more likely to develop when one or more of these factors is present: low birth weight maternal diabetes older paternal age famine oxygen depriva0on during delivery maternal virus during mid ­pregnancy impairing brain development Schizophrenia is more likely to develop in babies born: during and aUer flu epidemics. in densely populated areas. a few months aUer flu season. aUer mothers had the flu during the second trimester, or had an0bodies showing viral infec0on. The lesson is to: get flu shots with early fall pregnancies. Understanding Schizophrenia Are there gene0c risk factors? If so, we would see more similar schizophrenia risk shared between iden0cal twins than fraternal twins (graph below). Do we? Genetic Factors If one twin has schizophrenia, the chance of the other one also having it are much greater if the twins are identical. Having adoptive siblings (or parents) with schizophrenia does not increase the likelihood of developing schizophrenia. Understanding Schizophrenia Genetic and Prenatal Causes Even in identical twins, genetics do not fully predict schizophrenia. This could be because of environmental differences. First difference: twins in separate placentas. Only one of two twins has the enlarged ventricles seen in schizophrenia. Even if maternal flu during the second trimester doubles the risk of schizophrenia, this means only 2 percent of these babi...
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This note was uploaded on 04/07/2014 for the course PSYCH 10 taught by Professor Zaidel during the Fall '08 term at UCLA.

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