Development of cardiovascular diseaseCoronary heart diseaseThe heart is a muscular pump. Like all muscles, it needs oxygenfor aerobic respiration to contract. The coronary arteriessupply blood, and therefore oxygen, to the heart muscle.The coronary arteries may become blocked by a build-up of fatty material, caused by certain kinds of 'bad' cholesterol. As the fatty material increases, oneor more coronary arteries narrow, and can become blocked.Error! Filename not specified.If a blockage builds up, the amount of oxygen reaching the heart muscle is reduced. A person will develop chest pain, and if left untreated, a heart attack is the result. This can cause damage to, or death of the heart muscle. Part of the heart muscle, or the whole heart, will die.Heart transplantsA heart transplant is required in cases of heart failure. Coronary heart disease can lead to heart failure. The heart fails to pump sufficient blood and organs are starved of oxygen. There are different degrees of severity of heart failure.