Beng 130 Handout-5

Beng 130 Handout-5 - Structure and Constituents of DNA and...

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Unformatted text preview: Structure and Constituents of DNA and RNA Adenine (A) Guanine (G) 6 7 +H\1 1 5 N / Purines *N l \>3/H —..H\ 2 2 /J\ N H N 4 N 3 QN 9 3 \ \ +H H H -’ denOtes H-bond donor Ailachmenlsilerorsugar * denotes H-bond acceptor Cytosine (C) Thymine (T) Uracii (U) (In DNA Oniy) (In RNA Only) Pyrimidines Attachment site for sugar Ribose (In RNA only) Deoxyribose (In DNA only) m nucleofides: binds '0 phosphate groups In nucleotides: blndS to phosphate groups In RNA forms phosphodlester bonds In DNA. forms phospho‘j‘esmr bonds Ho—CH2 OH HO—CH2 OH Attachment Slle for base Forms phosphodlesler bond Page 1 of 4 Attaches to _5_' carbon of riboss or deoxyribose PHOSPHATES O O O O O O o‘—Il=!—o—R o—IDI—o—u—o—m—R OZ-WLI—O—FU—O—g—O—R In Nucleotides (I; (if (I)‘ ('3' ('3' Cl)- Monophosphate Diphosphate Triphosphafe //-r R\ Attaches to 3 carbon of ribose or deoxyr‘tbose O In DNA and RNA _ | l Attaches to §_' carbon of ribose or deoxyribose NUCLEOTIDES Tuning tfiem alftogetfier... Example: dATP deoxyr'rbose triphosphaie adenosine Example: CMP ribose by defaurt T monophosphate cytidine Page 2 of 4 ‘ right-handed * has major and minor grooves DNA Structure Example: 5'-A-C-G T—3' 3‘-T-G-C-A-5' 3' end OH I H _ O H 5 end \N/H , _ V W o- 0 _ | N H/N \ N H C O 2 _ thymine H I Ozp—o' 0—CH2 o N A O i N adenine H 0 fl 0 H \ OL—ILZO / ‘ ' H /N HZC—HT cl)——CH H /& N guanine OZPWO- 2 o N 0 no \ i O H cytosine H \ H‘“ H N .0 N N/ (I) H o/l o“ P—*O 4 N / Hzc—O O—CH 2 o \ H t . l N H/N\ cy osme 0 guanine o H N 1 O / N O 01"“‘PZO / >\ rho—(l3 N A I H H \ / H O=P—-—O o-—-(:H2 N N/ N I O or N adenine 5' end . C - OH thymine H5 3' end Page 3 of 4 RNA Structure ?;fgér(§:czisbggrenszN:r)s:tfucture: Example: 5'-A-C-G-U-3‘ 9 2) Uracil in place of Thymine 3) Single-stranded (no base pairing) 5' end H \N/H O- _ I N O--~F|>=0 H / \N O N H adenine T (I) OH N——H o‘—P=o I / \ o—CH2 O N\< O H cytosine \N/H T OH A 043,20 N/ N/H O——-~CH2 O N \ L o “N O OH guanine O o'—P:o / I NH 0—CH2 0 N uracil OH OH 3' end Page 4 of 4 ...
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Beng 130 Handout-5 - Structure and Constituents of DNA and...

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