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Unformatted text preview: for the active site competitive inhibition Some permanently bind Why is methanol poisonous o Methanol is an accidental by product of distillation Illegal in most states to distill alcohol without a license o Binds to same site as ethanol in alcohol dehydrogenase o ADH converts methanol to formaldehyde o Formaldehyde pickles the brain, causes blindness, among other things o Treatment: ethanol Some drugs and poisons binds active site permanently o Acethylcholinesterase Breaks down acetylcholine, a neurotransmitter Ach freese synapses of free acetylcholine In the absence of Ach, muscles, glands, CNS are overstimulated Sarin gas (nerve gas used in warfare) is an acetylcholinesterase Insecticides target the ACh in certain insects Environmental conditions o Three-dimensional structure of an enzyme is sensitive to pH, salts, temperature ect. o...
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