Lecture 6 Transport Across Epithelia 1 - MitchellThom OccludingJunctions o o o Ie.Smallintestines,kidneyt

Lecture 6 Transport Across Epithelia 1 - MitchellThom...

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Cell Physiology Lecture 6 September 20 2013 Transport Across Epithelium Mitchell Thom - Occluding Junctions o Proteins that rivet together cell membranes in a very tight junction o Almost nothing can move between these o Commonly found in polarized epithelia Ie. Small intestines, kidney tubules, blood-brain  barrier….anywhere you don’t want movement between  membranes o Leakiness are altered due to tight junction changes - Kidney Tubule Tight Junctions o Woods’ favourite tissue type! o o Filtering apparatus filters blood and filtrate is what is filtered out o Filtrate passes through the Proximal Tubule first,  Known as the “leaky” part of the nephron. LOTS of paracellular  motion goes on here o then the (Descending/)Ascending loop of Henle Some paracellular transport o lastly the Collecting Duct NO paracellular motion
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o Isn’t just a garden hose, it is cellular o o Filtrate moves over the top of the cells and may be reabsorbed between  cells or through the cells o Motion of a molecule between cells in reabsorption is called  paracellular  motion o The dots between cells are occluding junctions! If it was too tight there  would be no paracellular motion and if it was loose, it would lead to 
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  • Fall '09
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