Lecture 10 Ion Channels - MitchellThom Potential(V:Volt(V mV(103V Current(I:Ampere(A)nA(109A,pA(1012A Resistance(R:Ohm(W MW(106W,GW(109W

Lecture 10 Ion Channels - MitchellThom Potential(V:Volt(V...

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Cell Phys Lecture 10 September 30 2013 Mitchell Thom - All Electrical Currents in the body rely on the same basic physics - Potential (V): Volt (V)       mV (10 -3  V) - Current (I): Ampere (A)     nA (10 -9  A), pA (10 -12  A) - Resistance (R): Ohm (W) MW (10 6  W), GW (10 9  W) - Conductance (G): Siemens(S)  nS (10 -9  S), pS (10 -12  S) - Electical Current and voltage o Current = movement of charges o The direction of current is the movement of positive charges from high to  low electrical potential (voltage) o o Height = V  o Ball rolling down hill = I o Hill can be smooth or sticky (resistance) - Electric Currents in Excitable Cells o In biological tissues, electrical activities are carried by ions Ions= cations and anions Cations: Na+, K+, Ca++, Mg++ Anions: HCO3- - Ohm’s Law o I= V/R o V=IR o G = conducatance = 1/R o I = GV o V I R I V R c o n d u c t o r - Brain, Neurons, and Channels o o in 1900s people realized there were many different shapes of neurons o have common properties in all different types of neurons all able to fire an action potential/all excitable because of their ion  channels
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o Sakmann and Neher measured a single channel recording in the  1970s - Membrane and Ion Channels o K + Cl - Na + K + Cl - Na + Ca 2+ Ca 2+
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