Lecture 4 Cell-Matrix Interactions 2 - MitchellThom , structureintheECM o

Lecture 4 Cell-Matrix Interactions 2 - MitchellThom ,...

This preview shows page 1 - 2 out of 5 pages.

Cell Physiology Lecture 4 September 16 2013 Cell Matrix Interactions II Mitchell Thom - Collagen is one of many components of the ECM, and it is the most abundant  structure in the ECM - The alpha helix of Collagen is called the  collagen fibril.   o The amino acids that are in the middle of the helix are Glycines. o o A usual repeating sequence is Glycine- Proline- Hydroxyproline o The N and C-terminus are globular domains that help to wind the trimer  together - Over 20 different types of Collagen o All 3 proteins in the repeating sequence of collagen can differ to create  different collagens. o Remember that collagens can also be homo or heterodimers depending on  if the individual components are from the same gene or not - - Collagens 1 2 3 are the common ones o In the ER the polypeptide chains are hydroxylated and then glycosylated o Proline and Lysine are the ones that are usually hydroxylated  Not all prolines and lysines! Hydroxylated lysines are glycosylated o Scurvy= lack of vitamin C leading to weak collagen Collagen cannot be hydroxylated without vitamin C How does hydroxylation lead to collagen integrity? o An oligosaccharide (multiple sugars) is added to the N-terminus in the  Golgi o The globular domains at the N and C terminus are cleaved out of the cell  where the fibrils then cross link (Fibrillogenesis) to form the ECM  suprastructure - Collagen VI o Multimer, not a trimer o Globular domains are not removed as they are a component of the  tropocollagen structure Therefore some collagens need the N and C globular domains to be removed, while some require them to function - Differences Between Collagen Types - Number of helix repeat: ie. The length of the triple helix portion
Image of page 1

Subscribe to view the full document.

Image of page 2
  • Fall '09
  • LEUNG
  • Golgi Apparatus, Collagen, Glycosaminoglycan, collagens

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern

Ask Expert Tutors You can ask 0 bonus questions You can ask 0 questions (0 expire soon) You can ask 0 questions (will expire )
Answers in as fast as 15 minutes