Lecture 5 Cell-Cell Interactions - MitchellThom glycosaminoglycans o o

Lecture 5 Cell-Cell Interactions - MitchellThom...

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Cell Phys Lecture 5 September 18 2013 Cell-Cell Interactions and Cell-ECM Interactions continued Mitchell Thom - Proteoglycans are NOT glycoproteins but they are glycosylated with  glycosaminoglycans o Glycosaminoglycans are SUPLHATED o This negative charge is important for the function of a proteoglycan - Collagen= structure - Proteoglycans= cushion - Differences between Proteoglycans o Number of GAGs o Length of GAGs o Type of GAGs o TYPE OF PROTEIN CORE 2 Major: Perlican o Mainly in basal lamina Aggrican o Name of protein core helps us name the  proteoglycan and defines it - Multi-adhesive proteins o Glue in the ECM o Bind to each other, to ECM, to integrins…etc o Long and flexible glycosylated proteins which work well to stick to other  components in the ECM o MOST COMMON=  FIBRONECTIN One gene for fibronectin. There isn’t a family of fibronectine Body will splice the gene in many different fashions so that many  pre-mRNA’s will be full length but many will also be modified What are the different products called? ISOFORMS Our body can nicely choose which fibronectin isoform it would  like to have Soluble isoform and Insoluble isoform Insoluble in ECM of the tissues of our body Soluble in ECM of blood of our body Fibronectin is involved in blood-clotting process o Fibronectin can morph into the insoluble form by  cells attaching to it. As the fibronectin is pulled and  stretched by the cells pulling on It, it opens a  hydrophobic domain that makes it now insoluble!
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  • Fall '09
  • cells, o Gap Junctions, adhesion molecules, DSC3

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