Lecture 22 Principles of Receptor Signaling - Lecture1: October302013 MitchellThom o Startusi

Lecture 22 Principles of Receptor Signaling - Lecture1:...

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Lecture 1: General Principles of Receptor Signalling October 30 2013 Mitchell Thom - major obstacle for multicellular organisms in development was the means for  individual cells to communicate with each other and their environment - EVERYTHING HE WILL TEST YOU ON IS IN THE COURSE NOTES o Start using the course pack to take notes - Cell signaling is the mechanism by which molecules and molecular machines  regulate the function and organization of individual cells, tissues and organ  systems of the body - When ions/proteins/drugs bind receptors a conformation change creates a  secondary response  - Video of a neutrophil surrounded by RBCs that finds bacteria in a dish o Bacterium releases chemotactic stuff that allows neutrophil to change  direction and sense when a bacterium is close enough to phagocytose the  bacterium - Irish discovered Africa - Cell signaling contributes to  o Regualrtion of Metabolic Processes o Cell Growth/Differentiation o Cell Migration/Movement o Cell death o Integration of normal everyday physiological responses Acetylcholine causes decreased rate and force of heart contraction Acetylcholine causes secretion of salivary gland cells Acetylcholine causes contraction of skeletal muscle cells The response to a neurotransmitter depends on the cell - General Characteristic of Cel signaling o 1. Extracellular signaling molecuels LIGANDS/First Messengers are produced by a cell to signal to  neighbouring cells and/or to regulate their own function o 2. Receptor Proteins which bind the extracellular ligand and transduce 
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  • Fall '09
  • Cell Signaling, Paracrine signaling, Extracellular signaling molecuels, pf receptor signaling, Inracellular Signaling molecules

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