biol1201 march 27

biol1201 march 27 - Human DNA does not incorporate AZT Why...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
3/27/08 Human DNA does not incorporate AZT. Why? Human DNA polymerase has a proof-reading ability The base pairing between strands is stabilized by hydrogen bonds “A” pairs with what base? The enzyme that inserts the RNA primer in the DNA synthesis primase DNA polymerase works 5’ to 3’: Adds to the 3’ hydroxyl Both the leading and lagging strands are synthesized 5’ to 3’ Stitches together Okazaki fragments? Ligase 1. DNA as the genetic material a. Studies with viruses (bacteriophages – bacteria eaters) b. In 1952, Hershey and Chase used the bacteriophage T2 i. Sulfur in proteins ii. Phosphate in DNA 2. Transforming bacteria a. Cause non-virulent bacteria to become virulent b. The “transforming” principle i. Griffith – 1928 – Streptococccus (Diplococcus) pneumoniae transforming principle ii. Avery, MacCleod, and McCarthy in 1944 demonstrated that DNA was the transforming principle 3. DNA a. 2 DeoxyriboNucleic Acid i. Watson and Crick, 1953, DNA structure and the implication for
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/10/2008 for the course BIOL 1201 taught by Professor Wishtichusen during the Spring '07 term at LSU.

Page1 / 3

biol1201 march 27 - Human DNA does not incorporate AZT Why...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online