Lecture_33_Review_Questions - Review questions for lecture...

Info icon This preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Review questions for lecture 33. 33.1) What makes the rough ER look different from the smooth ER in the electron microscope, and where is this distinguishing feature observed: in the ER lumen or on the cytoplasmic side of the ER. In the electron microscope the distinguishing feature of rough ER from smooth ER is that Rough ER is studded with little black dots [ribosomes and polyribosomes] observed on the cytoplasmic side of the ER membrane. Correct 33.2) Where is the site of phospholipid synthesis in a cell? Endoplasmic Reticulum Correct 33.3) What are the roles of each of the following proteins during co-translational transport: SRP, SRP receptor, signal sequence, protein translocator, signal peptidase. SRP – or signal recognition particle, recognizes and binds to ER signal sequence on partially synthesized, nascent polypeptide chain and directs polypeptide/ribosome complex to ER Correct SRP receptor – integral membrane protein, exposed only on cytosolic side of rough ER membrane that binds SPR/ribosome/polypeptide complex and directs it to the protein translocator Almost correct except that it is a transmembrane protein so it is exposed to the cytosol and the lumen of the ER. Recall, that transmembrane domains always span the bilayer.
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern