Glucose Oxidation - Glucose Oxidation A. Cellular...

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Glucose Oxidation A. Cellular Respiration 1. Overall reaction 6H 2 O + 6O 2 + C 6 H 12 O 6 → 6CO 2 +12H 2 O + available energy a. Glycolysis - Glucose (6C) → 2 Pyruvic acid (3C) b. Formation of acetyl CoA - 2 Pyruvic Acid → 2 acetyl CoA c. Citric acid cycle d. electron transport chain (chemiosmosis) 2. Glycolysis a. occurs in cytoplasm b. can occur under aerobic or anaerobic conditions - does not require oxygen c. Glycolysis steps Glucose ATP ADP Glucose 6 PO 4 Fructose 6 PO 4 ATP ADP Fructose 1,6 bisPO 4 Dihydroxy acetone Isomerase 3 Phosphoglyceraldehide (3PGA) Phosphate (DHAP) P i NAD + (reduced to NADH) Exergonic Endergonic Same As Left NADH 1, 3 bisphosphoglycerate (bisphosglyceric acid) ADP ATP 3 phosphoglyceric acid 2 phosphoglyceric acid H 2 O Phosphoenol pyruvate (PEP) ADP ATP Pyruvic Acid Pyruvic Acid
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- step 1- Activation energy – activating glucose - step 2- Rearrangement - step 3- Adding energy- activating molecules - step 4- splits molecule - step 5- Rearranging DHAP → 3PGA - step 6- NAD + reduces to NADH; adds an inorganic phosphate oxidizes 3 phosphoglyceraldehide - step 7- Substrate level phosphorylation- direct synthesis of ATP using substrate energy (labile - bonds in the phosphate group easily broken for energy - step 8- Rearrangement 3→2 phosphoglycerate
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This note was uploaded on 04/07/2008 for the course BS 131 taught by Professor Smith during the Spring '08 term at University of the Sciences in Philadelphia.

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Glucose Oxidation - Glucose Oxidation A. Cellular...

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