ch06_lecture-Ground Rules of Metabolism

ch06_lecture-Ground Rules of Metabolism - Ground Rules of...

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Ground Rules of Metabolism Chapter 6
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Free Radicals Unbound molecular fragments with the wrong number of electrons Highly reactive Can disrupt structure of molecules
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Keeping Free Radicals in Check superoxide dismutase catalase Figure 6.1 Page 96
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Superoxide Dismutase Catalyzes the formation of hydrogen peroxide from oxygen-free radicals and hydrogen ions Accumulation of hydrogen peroxide can be lethal to cells
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Catalase Catalyzes the formation of oxygen and water from hydrogen peroxide 2H 2 O 2 ----------> 2H 2 O + O 2
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Roundworm Experiments Diet supplemented with superoxide dismutase and catalase increased life span of normal worms Diet also allowed worms genetically engineered for susceptibility to free radicals to live normal life span
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What Is Energy? Capacity to do work Forms of energy Potential energy Kinetic energy Chemical energy
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What Can Cells Do with Energy? Energy inputs become coupled to energy-requiring processes Cells use energy for: Chemical work Mechanical work Electrochemical work
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First Law of Thermodynamics The total amount of energy in the universe remains constant Energy can undergo conversions from one form to another, but it cannot be created or destroyed
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One-Way Flow of Energy The sun is life’s primary energy source Producers trap energy from the sun and convert it into chemical bond energy All organisms use the energy stored in the bonds of organic compounds to do work
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Second Law of Thermodynamics No energy conversion is ever 100 percent efficient The total amount of energy is flowing from high-energy forms to forms lower in energy
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This document was uploaded on 02/21/2008.

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ch06_lecture-Ground Rules of Metabolism - Ground Rules of...

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