Chapter_5 - Chapter 5 Neoplasia Introduction A. neoplasm...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Chapter 5 – Neoplasia Introduction A. neoplasm – new thing formed a. autonomous growth of tissue b. abnormal ell proliferation c. may be different from precursor B. solid neoplasms (tumors) a. localized -> benign b. spreading -> malignant/cancer Cancer A. ancient disease B. incidence increase with age -> cells cannot deal with stress a. longer life = increase population at risk b. increase cancer rate is related to increase in population age c. remove smoking enhancers, we are not increasing cancer rates Generalities A. irreversible autonomous growth B. derived from cells that usually proliferate C. degree of proliferation will vary D. initiating stimulus often unknown E. arises from mutation in growth, apoptosis, and repair genes Benign v.s. Malignant A. benign a. non-invasive b. do not metastasize to distant sites c. more differentiation d. usually spare host (except critical locations), i.e. tumor growing aggressively in the brain creates pressure on the brain preventing formation of CSF and functions B. malignant a. invasive b. able to metastasize to distant sites c. range of differentiation d. usually kill host 1. exception – surgical remove/cure 2. some connective and breast tumors C. tumors are difficult to classify a. basal cell carcinoma 1. histologically malignant 2. rarely metastasize b. pleomorphic adenoma 1. benign Classification A. benign and malignant are both derived by tissue organs? B. “-oma” implies benign, preceded by tissue of origin a. chrondroma – cells resemble chrondrocytes b. lipoma – fatty tumors c. fibroma – fibrous tissue tumor d. chondroblastoma – tumor resembles precursor of chondrocytes (blast-immature cell type) e. hamatoma – connective, branched vessels C. “carcinoma” implies malignant tumors a. carcinoma – epithelial origin
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
b. sarcoma – mesenchymal origin 1. i.e. malignant tumor of the stomach – gastric adenocarcinoma 2. squamous cell carcinoma – invasive skin tumor 3. chondrosarcoma, fibrosarcoma c. name sometimes suggest tissue of origin 1. osteogenic sarcoma 2. bronchogenic sarcoma d. exception in nomenclature (all malignant) 1. hepatoma – tumors of liver 2. melanoma – 3. seminoma – tumors of testes 4. lymphoma – tumors of lymphatic tissues 5. leukemia – malignant proliferation of leukocytes Secondary Descriptors A. papillary – frond-like structure B. medullary – soft cellular tissue C. scirrhous/desmoplastic – dense fibrous stoma D. colloid carcinomas – secrete abundant mucus E. comedocarcinoma – necrotic material that can be expressed (intraductal) F. tissues with poor histogenesis are given eponyms, i.e. Hodgkins disease, Ewing sarcoma Histologic Diagnosis of Malignancy A. no reliable molecular indicators B. based on microscopy C. judgment call (in some cases) Benign Tumors A. tend to be similar to parent tissue B. not able to invade C. may be encapsulated with connective tissue or non-encapsulated Histologic Features of Malignant Tumors A. anaplasia or cellular atypia
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/07/2008 for the course PHS 3510 taught by Professor Hardej during the Spring '08 term at St. Johns Duplicate.

Page1 / 14

Chapter_5 - Chapter 5 Neoplasia Introduction A. neoplasm...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online