Guilford Technical Community CollegeNUR 114: 10 Steps to Learning Success GridAnatomy andPhysiologyPathophysiologyRisk FactorsClinical ManifestationsSigns and SymptomsConcept: PerfusionExemplar:Deep VeinThrombosisVirchow triad,are associated withthrombophlebitis:Stasis of blood, Vesseldamage, Increased blood coagulability1.Vessel trauma stimulates theclotting cascade.2.Platelets aggregate at site, morecommon when venous stasis inpresent.3.Platelets and fibrin form clots.4.Red blood cells are trapped inmeshwork.5.Inflammatory response triggeredcausing: tenderness, swelling,erythema in area.6.Thrombus floats within vein.Pieces may break off and travelthrough circulatory systemcausing an emboli.7.Fibroblast invade thrombuscausing scarring and destroyingvein valves.8.Valve damage will most likelyaffect venous flow.DVT occurs in the body’s deep veins,those leading to the vena cava. Locationsinclude: pelvis, calf, thigh. Less commonare arm, chest, and other locations.DVT is common complication inhospitalizations, surgery, andimmobilization.Orthopedic Procedures:examples include total hipreplacement, hip fracture, totalknee replacement.Atrial Fibrillation:A-fib cancause thrombi within atria thatcan enter general circulationand cause stroke.
